Literatureresearch
XIA Fangmei, XU Minfang, LI Yingchun
Objective To evaluate the efficacy and safety of acupoint application combined with Chinese medicine fumigation(TCM) in the treatment of diabetic peripheral neuropathy(DPN). Methods Randomized controlled trials (RCTs) on acupoint application combined with Chinese herbal fumigation in the treatment of diabetic peripheral neuropathy were searched in China National Knowledge Infrastructure(CNKI), Wanfang Data, VIP Database, PubMed and other databases. Literature screening, data extraction and quality evaluation were conducted by two researchers independently. RevMan 5.3 were applied for statistical analysis of the data. Results Twelve articles were selected, including 597 patients in the experimental group and 597 ones in the control group. The results of Meta-analysis showed that such treatment improved the total effective rate of diabetic peripheral neuropathy treatment [OR=5.42,95%CI(3.60,8.16), P<0.001] , the traditional Chinese medicine(TCM) syndrome score[SMD=-2.68,95%CI(-4.02,-1.33),P<0.001], and Toronto clinical scoring system score[SMD=-1.61,95%CI (-2.37,-0.85),P<0.001]. Moreover, the sensory and motor nerve conduction velocity of the median nerve[SMD=0.78,95%CI(0.38,1.17),P<0.001;SMD=0.76,95%CI(0.35,1.17),P<0.001], common peroneal nerve [SMD=1.24,95%CI(0.72,1.77),P<0.001;SMD=1.60,95%CI(0.83,2.38),P<0.001] and tibial nerve[SMD=0.83,95%CI(0.43,1.24),P<0.001; SMD=0.77, 95%CI(0.42,1.12),P<0.001] of the experimental group was significantly better than those of the control group. Conclusion Acupoint application combined with Chinese medicine fumigation can improve the efficacy and nerve conduction velocity of DPN. However, large-scale, multi-center and high-quality RCTs are needed to verify the exact efficacy.